Loss of Tdp-43 disrupts the axonal transcriptome of motoneurons accompanied by impaired axonal translation and mitochondria function

Loss of Tdp-43 disrupts the axonal transcriptome of motoneurons accompanied by impaired axonal translation and mitochondria function

Abstract Protein inclusions containing the RNA-binding protein TDP-43 are a pathological hallmark of amyotrophic lateral sclerosis and other neurodegenerative disorders. The loss of TDP-43 function that is associated with these inclusions affects post-transcriptional processing of RNAs in multiple w...

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Bibliographic Details
Main Authors: Michael Briese, Lena Saal-Bauernschubert, Patrick Lüningschrör, Mehri Moradi, Benjamin Dombert, Verena Surrey, Silke Appenzeller, Chunchu Deng, Sibylle Jablonka, Michael Sendtner
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Acta Neuropathologica Communications
Subjects:
Amyotrophic lateral sclerosis
Tdp-43
Axonal transcriptome
Nicotinamide
Online Access:http://link.springer.com/article/10.1186/s40478-020-00987-6

Internet

http://link.springer.com/article/10.1186/s40478-020-00987-6

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