Dual and Opposite Costimulatory Targeting with a Novel Human Fusion Recombinant Protein Effectively Prevents Renal Warm Ischemia Reperfusion Injury and Allograft Rejection in Murine Models

Dual and Opposite Costimulatory Targeting with a Novel Human Fusion Recombinant Protein Effectively Prevents Renal Warm Ischemia Reperfusion Injury and Allograft Rejection in Murine Models

Many studies have shown both the CD28—D80/86 costimulatory pathway and the PD-1—PD-L1/L2 coinhibitory pathway to be important signals in modulating or decreasing the inflammatory profile in ischemia-reperfusion injury (IRI) or in a solid organ transplant setting. The importance of these two opposing...

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Bibliographic Details
Main Authors: Jordi Guiteras, Laura De Ramon, Elena Crespo, Nuria Bolaños, Silvia Barcelo-Batllori, Laura Martinez-Valenzuela, Pere Fontova, Marta Jarque, Alba Torija, Oriol Bestard, David Resina, Josep M Grinyó, Joan Torras
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
costimulation
coinhibition
ischemia-reperfusion injury
kidney transplant
SPR
protein binding affinity
Online Access:https://www.mdpi.com/1422-0067/22/3/1216

Internet

https://www.mdpi.com/1422-0067/22/3/1216

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