Dual and Opposite Costimulatory Targeting with a Novel Human Fusion Recombinant Protein Effectively Prevents Renal Warm Ischemia Reperfusion Injury and Allograft Rejection in Murine Models
Many studies have shown both the CD28—D80/86 costimulatory pathway and the PD-1—PD-L1/L2 coinhibitory pathway to be important signals in modulating or decreasing the inflammatory profile in ischemia-reperfusion injury (IRI) or in a solid organ transplant setting. The importance of these two opposing...
Main Authors: | Jordi Guiteras, Laura De Ramon, Elena Crespo, Nuria Bolaños, Silvia Barcelo-Batllori, Laura Martinez-Valenzuela, Pere Fontova, Marta Jarque, Alba Torija, Oriol Bestard, David Resina, Josep M Grinyó, Joan Torras |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-01-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/22/3/1216 |
Similar Items
-
MUC1 is a novel costimulatory and coinhibitory molecule of human T cells
by: Konowalchuk, Jeffrey
Published: (2009) -
T cell costimulatory and coinhibitory pathways in vascular inflammatory diseases
by: Andrew eLichtman
Published: (2012-02-01) -
The viral context instructs the redundancy of costimulatory pathways in driving CD8+ T cell expansion
by: Suzanne PM Welten, et al.
Published: (2015-08-01) -
Neuroimmune semaphorins as costimulatory molecules and beyond
by: Svetlana P. Chapoval
Published: (2018-04-01) -
Roles of BTLA in Immunity and Immune Disorders
by: Zhaochen Ning, et al.
Published: (2021-03-01)