HLA-DRB1 Alleles Associated with Lower Leishmaniasis Susceptibility Share Common Amino Acid Polymorphisms and Epitope Binding Repertoires

HLA-DRB1 Alleles Associated with Lower Leishmaniasis Susceptibility Share Common Amino Acid Polymorphisms and Epitope Binding Repertoires

Susceptibility for leishmaniasis is largely dependent on host genetic and immune factors. Despite the previously described association of human leukocyte antigen (HLA) gene cluster variants as genetic susceptibility factors for leishmaniasis, little is known regarding the mechanisms that underpin th...

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Bibliographic Details
Main Authors: Nicky de Vrij, Pieter Meysman, Sofie Gielis, Wim Adriaensen, Kris Laukens, Bart Cuypers
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Vaccines
Subjects:
<i>Leishmania</i>
immunoinformatics
antigen presentation
HLA association
leishmaniasis
vaccine candidates
Online Access:https://www.mdpi.com/2076-393X/9/3/270

Internet

https://www.mdpi.com/2076-393X/9/3/270

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