Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancer

Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancer

Prostate cancers often become castration resistant due to alternative expression of androgen receptor (AR) splice variants. Here, the authors screened a library of natural compounds and identified Ailanthone as a potent inhibitor of AR through its binding to the co-chaperone protein p23 that, by pre...

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Bibliographic Details
Main Authors: Yundong He, Shihong Peng, Jinhua Wang, Huang Chen, Xiaonan Cong, Ang Chen, Meichun Hu, Min Qin, Haigang Wu, Shuman Gao, Liguo Wang, Xin Wang, Zhengfang Yi, Mingyao Liu
Format: Article
Language:English
Published: Nature Publishing Group 2016-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms13122

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https://doi.org/10.1038/ncomms13122

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