Lack of Correlation between In Vitro and In Vivo Studies on the Inhibitory Effects of (‒)-Sophoranone on CYP2C9 Is Attributable to Low Oral Absorption and Extensive Plasma Protein Binding of (‒)-Sophoranone

Lack of Correlation between In Vitro and In Vivo Studies on the Inhibitory Effects of (‒)-Sophoranone on CYP2C9 Is Attributable to Low Oral Absorption and Extensive Plasma Protein Binding of (‒)-Sophoranone

(‒)-Sophoranone (SPN) is a bioactive component of <i>Sophora tonkinensis</i> with various pharmacological activities. This study aims to evaluate its in vitro and in vivo inhibitory potential against the nine major CYP enzymes. Of the nine tested CYPs, it exerted the strongest inhibitory...

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Bibliographic Details
Main Authors: Yu Fen Zheng, Soo Hyeon Bae, Zhouchi Huang, Soon Uk Chae, Seong Jun Jo, Hyung Joon Shim, Chae Bin Lee, Doyun Kim, Hunseung Yoo, Soo Kyung Bae
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Pharmaceutics
Subjects:
(‒)-sophoranone
CYP2C9
potent inhibition
in vitro
in vivo
drug interaction
Online Access:https://www.mdpi.com/1999-4923/12/4/328

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https://www.mdpi.com/1999-4923/12/4/328

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