Lipopolysaccharide Induces Autophagic Cell Death through the PERK-Dependent Branch of the Unfolded Protein Response in Human Alveolar Epithelial A549 Cells

Lipopolysaccharide Induces Autophagic Cell Death through the PERK-Dependent Branch of the Unfolded Protein Response in Human Alveolar Epithelial A549 Cells

Background: Alveolar epithelial cell death plays a critical role in the pathogenesis of lipopolysaccharide (LPS)-induced acute lung injury. Increased autophagy has a dual effect on cell survival. However, it is not known whether autophagy promotes death or survival in human alveolar epithelial cells...

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Bibliographic Details
Main Authors: Shaoying Li, Liang Guo, Pin Qian, Yunfeng Zhao, Ao Liu, Fuyun Ji, Liutong Chen, Xueling Wu, Guisheng Qian
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
LPS
Autophagy
Unfolded protein response
Endoplasmic reticulum stress
PERK
Online Access:http://www.karger.com/Article/FullText/430202

Internet

http://www.karger.com/Article/FullText/430202

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