Intrauterine ischemic reperfusion switches the fetal transcriptional pattern from HIF-1α- to P53-dependent regulation in the murine brain.

Intrauterine ischemic reperfusion switches the fetal transcriptional pattern from HIF-1α- to P53-dependent regulation in the murine brain.

Ischemic reperfusion (IR) during the perinatal period is a known causative factor of fetal brain damage. So far, both morphologic and histologic evidence has shown that fetal brain damage can be observed only several hours to days after an IR insult has occurred. Therefore, to prevent fetal brain da...

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Bibliographic Details
Main Authors: Yupeng Dong, Takuya Ito, Clarissa Velayo, Takafumi Sato, Keita Iida, Miyuki Endo, Kiyoe Funamoto, Naoaki Sato, Nobuo Yaegashi, Yoshitaka Kimura
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4201554?pdf=render

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http://europepmc.org/articles/PMC4201554?pdf=render

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