PAR-2 Deficient CD4+ T Cells Exhibit Downregulation of IL-4 and Upregulation of IFN-γ after Antigen Challenge in Mice

PAR-2 Deficient CD4+ T Cells Exhibit Downregulation of IL-4 and Upregulation of IFN-γ after Antigen Challenge in Mice

Background: To investigate the functional role of protease activated receptor (PAR) -2 in T lymphocytes, we analyzed TCR-mediated inflammatory cytokine production using PAR-2 deficient (KO) and wild type (WT) mice. Methods: Production of serum IgE and cytokines by spleen CD4+ T cells was determined...

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Bibliographic Details
Main Authors: Michitaka Shichijo, Shinichi Kondo, Mina Ishimori, Shinichi Watanabe, Heidi Helin, Tsugiko Yamasaki, Mary E Stevens, Florian Gantner, Kevin B Bacon
Format: Article
Language:English
Published: Elsevier 2006-01-01
Series:Allergology International
Subjects:
CD4+ T cell
GATA-3
JNK1
PAR-2
T-bet
Online Access:http://www.sciencedirect.com/science/article/pii/S132389301530976X

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http://www.sciencedirect.com/science/article/pii/S132389301530976X

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