JVG9, a benzimidazole derivative, alters the surface and cytoskeleton of Trypanosoma cruzi bloodstream trypomastigotes

JVG9, a benzimidazole derivative, alters the surface and cytoskeleton of Trypanosoma cruzi bloodstream trypomastigotes

Trypanosoma cruzi has a particular cytoskeleton that consists of a subpellicular network of microtubules and actin microfilaments. Therefore, it is an excellent target for the development of new anti-parasitic drugs. Benzimidazole 2-carbamates, a class of well-known broad-spectrum anthelmintics, hav...

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Bibliographic Details
Main Authors: Dylan L Díaz-Chiguer, Francisco Hernández-Luis, Benjamín Nogueda-Torres, Rafael Castillo, Olivia Reynoso-Ducoing, Alicia Hernández-Campos, Javier R Ambrosio
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2014-09-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
Trypanosoma cruzi
benzimidazole
cytoskeleton
tubulin
actin
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000600757&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000600757&lng=en&tlng=en

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