Immune Checkpoint Inhibitors Regulate K+ Channel Activity in Cytotoxic T Lymphocytes of Head and Neck Cancer Patients

Immune Checkpoint Inhibitors Regulate K+ Channel Activity in Cytotoxic T Lymphocytes of Head and Neck Cancer Patients

Programmed death receptor-1 (PD-1) and its ligand (PD-L1) interaction negatively regulates T cell function in head and neck squamous cell carcinoma (HNSCC). Overexpression of PD-1 reduces intracellular Ca2+ fluxes, and thereby T cell effector functions. In HNSCC patients, PD-1 blockade increases KCa...

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Bibliographic Details
Main Authors: Vaibhavkumar S. Gawali, Ameet A. Chimote, Hannah S. Newton, Manuel G. Feria-Garzón, Martina Chirra, Edith M. Janssen, Trisha M. Wise-Draper, Laura Conforti
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Pharmacology
Subjects:
ion channels
immune checkpoint inhibitors
KCa3.1 (intermediate-conductance Ca2+-activated K+ channel)
Kv1.3 channel
Ca2+ signalling
head and neck (H&N) cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.742862/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.742862/full

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