Integrin α2β1-targeting ferritin nanocarrier traverses the blood–brain barrier for effective glioma chemotherapy

Integrin α2β1-targeting ferritin nanocarrier traverses the blood–brain barrier for effective glioma chemotherapy

Abstract Background Ferritin, the natural iron storage protein complex, self-assembles into a uniform cage-like structure. Human H-ferritin (HFn) has been shown to transverse the blood–brain barrier (BBB) by binding to transferrin receptor 1 (TfR1), which is abundant in endothelial cells and overexp...

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Bibliographic Details
Main Authors: Chiun-Wei Huang, Chia-Pao Chuang, Yan-Jun Chen, Hsu-Yuan Wang, Jia-Jia Lin, Chiung-Yin Huang, Kuo-Chen Wei, Feng-Ting Huang
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Journal of Nanobiotechnology
Subjects:
Ferritin
Integrin α2β1
Transferrin receptor 1
Receptor-mediated transcytosis (RMT)
Blood–brain barrier
Online Access:https://doi.org/10.1186/s12951-021-00925-1

Internet

https://doi.org/10.1186/s12951-021-00925-1

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