Ipriflavone attenuates the degeneration of cartilage by blocking the Indian hedgehog pathway

Ipriflavone attenuates the degeneration of cartilage by blocking the Indian hedgehog pathway

Abstract Background To determine if ipriflavone, a novel and safe inhibitor of Indian hedgehog (Ihh) signaling, can attenuate cartilage degeneration by blocking the Ihh pathway. Methods Human chondrocytes were used to evaluate Ihh signaling, cell proliferation, apoptosis, gene, and protein expressio...

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Bibliographic Details
Main Authors: Li Guo, Xiaochun Wei, Zhiwei Zhang, Xiaojian Wang, Chunli Wang, Pengcui Li, Chunfang Wang, Lei Wei
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Arthritis Research & Therapy
Subjects:
Ipriflavone
Osteoarthritis
Indian hedgehog
Chondrocyte hypertrophy
Online Access:http://link.springer.com/article/10.1186/s13075-019-1895-x

Internet

http://link.springer.com/article/10.1186/s13075-019-1895-x

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