Tin Mesoporphyrin Selectively Reduces Non-Small-Cell Lung Cancer Cell Line A549 Proliferation by Interfering with Heme Oxygenase and Glutathione Systems

Tin Mesoporphyrin Selectively Reduces Non-Small-Cell Lung Cancer Cell Line A549 Proliferation by Interfering with Heme Oxygenase and Glutathione Systems

In order to maintain redox homeostasis, non-small-cell lung cancer (NSCLC) increases the activation of many antioxidant systems, including the heme-oxygenase (HO) system. The overexpression of HO-1 has been often associated with chemoresistance and tumor aggressiveness. Our results clearly showed an...

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Bibliographic Details
Main Authors: Valeria Sorrenti, Agata Grazia D’Amico, Ignazio Barbagallo, Valeria Consoli, Salvo Grosso, Luca Vanella
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Biomolecules
Subjects:
cancer
heme-oxygenase
porphyrins
oxidative stress
Online Access:https://www.mdpi.com/2218-273X/11/6/917

Internet

https://www.mdpi.com/2218-273X/11/6/917

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