Viral Ubiquitin Ligase Stimulates Selective Host MicroRNA Expression by Targeting ZEB Transcriptional Repressors

Viral Ubiquitin Ligase Stimulates Selective Host MicroRNA Expression by Targeting ZEB Transcriptional Repressors

Infection with herpes simplex virus-1 (HSV-1) brings numerous changes in cellular gene expression. Levels of most host mRNAs are reduced, limiting synthesis of host proteins, especially those involved in antiviral defenses. The impact of HSV-1 on host microRNAs (miRNAs), an extensive network of shor...

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Bibliographic Details
Main Authors: Gabriel Lutz, Igor Jurak, Eui Tae Kim, Ju Youn Kim, Michael Hackenberg, Andrew Leader, Michelle L. Stoller, Donna M. Fekete, Matthew D. Weitzman, Donald M. Coen, Angus C. Wilson
Format: Article
Language:English
Published: MDPI AG 2017-08-01
Series:Viruses
Subjects:
herpes simplex virus
HSV-1
microRNA
miR-183
miR-96
miR-182
ICP0
E3 ubiquitin ligase
ZEB
host shutoff
Online Access:https://www.mdpi.com/1999-4915/9/8/210

Internet

https://www.mdpi.com/1999-4915/9/8/210

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