miR-221-5p enhances cell proliferation and metastasis through post-transcriptional regulation of SOCS1 in human prostate cancer

miR-221-5p enhances cell proliferation and metastasis through post-transcriptional regulation of SOCS1 in human prostate cancer

Abstract Background To investigate the effect of miR-221-5p on cell proliferaton and metastasis of human prostate cancer in vitro and vivo. Methods We established PC3 cell lines with stable overexpression or silencing of miRNA-221-5p via lentivirus infection. miRNA-221-5p and its target gene SOCS1 e...

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Bibliographic Details
Main Authors: Ning Shao, Gui Ma, Jinying Zhang, Wei Zhu
Format: Article
Language:English
Published: BMC 2018-03-01
Series:BMC Urology
Subjects:
Prostate cancer
miR-221-5p
SOCS1
Cell proliferation
Cell migration
Tumor xenograft
Online Access:http://link.springer.com/article/10.1186/s12894-018-0325-8

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http://link.springer.com/article/10.1186/s12894-018-0325-8

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