Tracing CLL-biased stereotyped immunoglobulin gene rearrangements in normal B cell subsets using a high-throughput immunogenetic approach

Tracing CLL-biased stereotyped immunoglobulin gene rearrangements in normal B cell subsets using a high-throughput immunogenetic approach

Abstract Background B cell receptor Immunoglobulin (BcR IG) repertoire of Chronic Lymphocytic Leukemia (CLL) is characterized by the expression of quasi-identical BcR IG. These are observed in approximately 30% of patients, defined as stereotyped receptors and subdivided into subsets based on specif...

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Main Authors: Monica Colombo, Davide Bagnara, Daniele Reverberi, Serena Matis, Martina Cardillo, Rosanna Massara, Luca Mastracci, Jean Louis Ravetti, Luca Agnelli, Antonino Neri, Michela Mazzocco, Margherita Squillario, Andrea Nicola Mazzarello, Giovanna Cutrona, Andreas Agathangelidis, Kostas Stamatopoulos, Manlio Ferrarini, Franco Fais
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Molecular Medicine
Online Access:http://link.springer.com/article/10.1186/s10020-020-00151-9

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http://link.springer.com/article/10.1186/s10020-020-00151-9

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