A Novel Resistance Pathway for Calcineurin Inhibitors in the Human-Pathogenic Mucorales Mucor circinelloides

A Novel Resistance Pathway for Calcineurin Inhibitors in the Human-Pathogenic Mucorales Mucor circinelloides

Mucor is intrinsically resistant to most known antifungals, which makes mucormycosis treatment challenging. Calcineurin is a serine/threonine phosphatase that is widely conserved across eukaryotes. When calcineurin function is inhibited in Mucor, growth shifts to a less virulent yeast growth form, w...

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Bibliographic Details
Main Authors: Sandeep Vellanki, R. Blake Billmyre, Alejandra Lorenzen, Micaela Campbell, Broderick Turner, Eun Young Huh, Joseph Heitman, Soo Chan Lee
Format: Article
Language:English
Published: American Society for Microbiology 2020-01-01
Series:mBio
Subjects:
mucor
mucormycosis
amino acid permease
calcineurin
dimorphism
drug resistance mechanisms
protein kinase a
Online Access:https://doi.org/10.1128/mBio.02949-19

Internet

https://doi.org/10.1128/mBio.02949-19

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