Dose-dependent artificial prolongation of prothrombin time by interaction between daptomycin and test reagents in patients receiving warfarin: a prospective in vivo clinical study

Dose-dependent artificial prolongation of prothrombin time by interaction between daptomycin and test reagents in patients receiving warfarin: a prospective in vivo clinical study

Abstract Background Daptomycin has been reported to cause artificial prolongation of prothrombin time (PT) by interacting with some test reagents of PT. This prolongation was particularly prominent with high concentrations of daptomycin in vitro. However, whether this prolongation is important in cl...

Full description

Bibliographic Details
Main Authors: Makoto Saito, Shuji Hatakeyama, Hideki Hashimoto, Takumitsu Suzuki, Daisuke Jubishi, Makoto Kaneko, Yukio Kume, Takehito Yamamoto, Hiroshi Suzuki, Hiroshi Yotsuyanagi
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Annals of Clinical Microbiology and Antimicrobials
Subjects:
Daptomycin
Prothrombin time
Warfarin
Drug resistance
Gram-positive infections
High dose
Online Access:http://link.springer.com/article/10.1186/s12941-017-0203-3

Internet

http://link.springer.com/article/10.1186/s12941-017-0203-3

Similar Items