Prevalence and Spectrum of Germline BRCA1 and BRCA2 Variants of Uncertain Significance in Breast/Ovarian Cancer: Mysterious Signals From the Genome

Prevalence and Spectrum of Germline BRCA1 and BRCA2 Variants of Uncertain Significance in Breast/Ovarian Cancer: Mysterious Signals From the Genome

About 10–20% of breast/ovarian (BC/OC) cancer patients undergoing germline BRCA1/2 genetic testing have been shown to harbor Variants of Uncertain Significance (VUSs). Since little is known about the prevalence of germline BRCA1/2 VUS in Southern Italy, our study aimed at describing the spectrum of...

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Bibliographic Details
Main Authors: Daniele Fanale, Alessia Fiorino, Lorena Incorvaia, Alessandra Dimino, Clarissa Filorizzo, Marco Bono, Daniela Cancelliere, Valentina Calò, Chiara Brando, Lidia Rita Corsini, Roberta Sciacchitano, Luigi Magrin, Alessia Pivetti, Erika Pedone, Giorgio Madonia, Alessandra Cucinella, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Oncology
Subjects:
BRCA1
BRCA2
breast cancer
genetic testing
ovarian cancer
variants of uncertain significance (VUS)
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.682445/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.682445/full

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