Neuronal deficiency of HIF prolyl 4-hydroxylase 2 in mice improves ischemic stroke recovery in an HIF dependent manner

Neuronal deficiency of HIF prolyl 4-hydroxylase 2 in mice improves ischemic stroke recovery in an HIF dependent manner

Hypoxia inducible factors (HIFs) mediate the endogenous adaptive responses to hypoxia. HIF prolyl 4-hydroxylase domain proteins (PHD) are important suppressors of the HIF pathway. Recently, we demonstrated that neuron-specific deletion of Phd2 reduces cerebral tissue damage in the very acute phase o...

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Bibliographic Details
Main Authors: Lexiao Li, Pamela Saliba, Stefan Reischl, Hugo H. Marti, Reiner Kunze
Format: Article
Language:English
Published: Elsevier 2016-07-01
Series:Neurobiology of Disease
Subjects:
PHD2
HIF
Neuron
Focal cerebral ischemia
Hypoxia
VEGF
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116300638

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http://www.sciencedirect.com/science/article/pii/S0969996116300638

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