Dioscin Promotes Prostate Cancer Cell Apoptosis and Inhibits Cell Invasion by Increasing SHP1 Phosphorylation and Suppressing the Subsequent MAPK Signaling Pathway

Dioscin Promotes Prostate Cancer Cell Apoptosis and Inhibits Cell Invasion by Increasing SHP1 Phosphorylation and Suppressing the Subsequent MAPK Signaling Pathway

Dioscin possesses antioxidant effects and has anticancer ability in many solid tumors including prostate cancer (PCa). Nevertheless, its effect and mechanism of anti-PCa action remain unclear. The tyrosine protein phosphatase SHP1, which contains an oxidation-sensitive domain, has been confirmed as...

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Bibliographic Details
Main Authors: Shuyun He, Jinrui Yang, Shaobo Hong, Haijian Huang, Qingguo Zhu, Liefu Ye, Tao Li, Xing Zhang, Yongbao Wei, Yunliang Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Pharmacology
Subjects:
dioscin
prostate cancer
cell apoptosis
cell invasion
SHP1
mitogen-activated protein kinase
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.01099/full

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https://www.frontiersin.org/article/10.3389/fphar.2020.01099/full

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