Site-specific PEGylation of lidamycin and its antitumor activity

Site-specific PEGylation of lidamycin and its antitumor activity

In this study, N-terminal site-specific mono-PEGylation of the recombinant lidamycin apoprotein (rLDP) of lidamycin (LDM) was prepared using a polyethyleneglycol (PEG) derivative (Mw 20 kDa) through a reactive terminal aldehyde group under weak acidic conditions (pH 5.5). The biochemical properties...

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Bibliographic Details
Main Authors: Liang Li, Boyang Shang, Lei Hu, Rongguang Shao, Yongsu Zhen
Format: Article
Language:English
Published: Elsevier 2015-05-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Enediyne antibiotic
Polyethylene glycol
Site-specific PEGylation
Lidamycin
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383515000490

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