Molecular Conversion of Muscarinic Acetylcholine Receptor M5 to Muscarinic Toxin 7 (MT7)-Binding Protein

Molecular Conversion of Muscarinic Acetylcholine Receptor M5 to Muscarinic Toxin 7 (MT7)-Binding Protein

Muscarinic toxin 7 (MT7) is a mamba venom peptide that binds selectively to the M1 muscarinic acetylcholine receptor. We have previously shown that the second (ECL2) and third (ECL3) extracellular loops of the M1 receptor are critically involved in binding the peptide. In this study we used a mutage...

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Bibliographic Details
Main Authors: Katja Näreoja, Johnny Näsman, Sergio Rondinelli
Format: Article
Language:English
Published: MDPI AG 2011-11-01
Series:Toxins
Subjects:
G protein-coupled receptor
muscarinic toxin
acetylcholine receptor
ligand binding
Online Access:http://www.mdpi.com/2072-6651/3/11/1393/

Internet

http://www.mdpi.com/2072-6651/3/11/1393/

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