TRPM4 regulates Akt/GSK3‐β activity and enhances β‐catenin signaling and cell proliferation in prostate cancer cells

TRPM4 regulates Akt/GSK3‐β activity and enhances β‐catenin signaling and cell proliferation in prostate cancer cells

Increased expression of the TRPM4 channel has been reported to be associated with the progression of prostate cancer. However, the molecular mechanism underlying its effect remains unknown. This work found that decreasing TRPM4 levels leads to the reduced proliferation of PC3 cells. This effect was...

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Bibliographic Details
Main Authors: Alfredo I. Sagredo, Eduardo A. Sagredo, Claudio Cappelli, Pablo Báez, Rodrigo E. Andaur, Constanza Blanco, Julio C. Tapia, César Echeverría, Oscar Cerda, Andrés Stutzin, Felipe Simon, Katherine Marcelain, Ricardo Armisén
Format: Article
Language:English
Published: Wiley 2018-02-01
Series:Molecular Oncology
Subjects:
ion channel
prostate cancer
TRPM4
Wnt
β‐catenin
Online Access:https://doi.org/10.1002/1878-0261.12100

Internet

https://doi.org/10.1002/1878-0261.12100

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