Iduronic acid in chondroitin/dermatan sulfate affects directional migration of aortic smooth muscle cells.

Aortic smooth muscle cells produce chondroitin/dermatan sulfate (CS/DS) proteoglycans that regulate extracellular matrix organization and cell behavior in normal and pathological conditions. A unique feature of CS/DS proteoglycans is the presence of iduronic acid (IdoA), catalyzed by two DS epimeras...

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Bibliographic Details
Main Authors: Barbara Bartolini, Martin A Thelin, Lena Svensson, Giancarlo Ghiselli, Toin H van Kuppevelt, Anders Malmström, Marco Maccarana
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3699603?pdf=render