Altered IHH signaling contributes to reduced chondrocyte proliferation in the growth plate of MPS VII mice

Altered IHH signaling contributes to reduced chondrocyte proliferation in the growth plate of MPS VII mice

Bone elongation is driven by chondrocyte proliferation and hypertrophy in the growth plate. Both processes are modulated by multiple signaling pathways including the Indian Hedgehog (IHH) signaling pathway. Mucopolysaccharidoses (MPS) are a group of lysosomal storage disorders characterized by accum...

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Bibliographic Details
Main Authors: Zhirui Jiang, Ainslie L.K. Derrick-Roberts, Sharon Byers
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Molecular Genetics and Metabolism Reports
Subjects:
Mucopolysaccharidosis (MPS)
Growth plate
Chondrocyte proliferation
Indian hedgehog (IHH)
Bone shortening
Online Access:http://www.sciencedirect.com/science/article/pii/S2214426920301142

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http://www.sciencedirect.com/science/article/pii/S2214426920301142

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