Overexpression of APOC1 in obob mice leads to hepatic steatosis and severe hepatic insulin resistance

Overexpression of APOC1 in obob mice leads to hepatic steatosis and severe hepatic insulin resistance

Obese obob mice with strong overexpression of the human apolipoprotein C1 (APOC1) exhibit excessive free fatty acid (FFA) and triglyceride (TG) levels and severely reduced body weight (due to the absence of subcutaneous adipose tissue) and skin abnormalities. To evaluate the effects of APOC1 overexp...

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Bibliographic Details
Main Authors: Martin Muurling, Anita M. van den Hoek, Ronald P. Mensink, Hanno Pijl, Johannes A. Romijn, Louis M. Havekes, Peter J. Voshol
Format: Article
Language:English
Published: Elsevier 2004-01-01
Series:Journal of Lipid Research
Subjects:
free fatty acid metabolism
lipid metabolism
hepatic fat accumulation
rosiglitazone
peroxisome proliferator-activated receptor-γ
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520319167

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http://www.sciencedirect.com/science/article/pii/S0022227520319167

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