Epithelial plasticity can generate multi-lineage phenotypes in human and murine bladder cancers

Epithelial plasticity can generate multi-lineage phenotypes in human and murine bladder cancers

Recent studies have utilized bulk tumour mRNA sequencing to classify bladder cancers into distinct subgroups. Here, the authors use single cell transcriptomic analysis and cell transplant studies to show that epithelial plasticity can generate basal, luminal and mesenchymal phenotypes in human and m...

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Bibliographic Details
Main Authors: John P. Sfakianos, Jorge Daza, Yang Hu, Harry Anastos, Geoffrey Bryant, Rohan Bareja, Ketan K. Badani, Matthew D. Galsky, Olivier Elemento, Bishoy M. Faltas, David J. Mulholland
Format: Article
Language:English
Published: Nature Publishing Group 2020-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16162-3

Internet

https://doi.org/10.1038/s41467-020-16162-3

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