Long Non-Coding RNA KCNQ1OT1 Promotes Cataractogenesis via miR-214 and Activation of the Caspase-1 Pathway

Long Non-Coding RNA KCNQ1OT1 Promotes Cataractogenesis via miR-214 and Activation of the Caspase-1 Pathway

Background/Aims: KCNQ1OT1 regulates the expression of tissue-specific imprinted genes within the Kcnq1 domain. Imprinted genes are positive regulators of apoptosis, one of the forms of cell death related to cataract formation, and thus may provide novel therapeutic targets for cataract treatment. He...

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Bibliographic Details
Main Authors: Xin Jin, Hao Jin, Yan Shi, Yiyuan Guo, Hong Zhang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-05-01
Series:Cellular Physiology and Biochemistry
Subjects:
Cataract
KCNQ1OT1
miR-214
Caspase-1
Pyroptosis
Online Access:http://www.karger.com/Article/FullText/477330

Internet

http://www.karger.com/Article/FullText/477330

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