Hypoxia promotes migration and induces CXCR4 expression via HIF-1α activation in human osteosarcoma.

Hypoxia promotes migration and induces CXCR4 expression via HIF-1α activation in human osteosarcoma.

Cellular adaptation to a hypoxic microenvironment is essential for tumor progression and is largely mediated by HIF-1α through coordinated regulation of hypoxia-responsive genes. The chemokine SDF-1α and its unique receptor CXCR4 have been implicated in organ-specific metastases of many cancers. In...

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Bibliographic Details
Main Authors: Mingjun Guo, Chengkui Cai, Guangyi Zhao, Xiuchun Qiu, Haien Zhao, Qiong Ma, Liying Tian, Xuelian Li, Yunsheng Hu, Bo Liao, Baoan Ma, Qingyu Fan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3949690?pdf=render

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http://europepmc.org/articles/PMC3949690?pdf=render

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