Self-recognition drives the preferential accumulation of promiscuous CD4+ T-cells in aged mice

T-cell recognition of self and foreign peptide antigens presented in major histocompatibility complex molecules (pMHC) is essential for life-long immunity. How the ability of the CD4+ T-cell compartment to bind self- and foreign-pMHC changes over the lifespan remains a fundamental aspect of T-cell b...

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Bibliographic Details
Main Authors: Neha R Deshpande, Heather L Parrish, Michael S Kuhns
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-07-01
Series:eLife
Subjects:
CD4
CD5
Online Access:https://elifesciences.org/articles/05949