Self-recognition drives the preferential accumulation of promiscuous CD4+ T-cells in aged mice
T-cell recognition of self and foreign peptide antigens presented in major histocompatibility complex molecules (pMHC) is essential for life-long immunity. How the ability of the CD4+ T-cell compartment to bind self- and foreign-pMHC changes over the lifespan remains a fundamental aspect of T-cell b...
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doaj-39ce88f28202492da7e89724c9b008bc2021-05-04T23:54:48ZengeLife Sciences Publications LtdeLife2050-084X2015-07-01410.7554/eLife.05949Self-recognition drives the preferential accumulation of promiscuous CD4+ T-cells in aged miceNeha R Deshpande0Heather L Parrish1Michael S Kuhns2Department of Immunobiology, University of Arizona College of Medicine, Tucson, United States; Arizona Center on Aging, University of Arizona College of Medicine, Tucson, United StatesDepartment of Immunobiology, University of Arizona College of Medicine, Tucson, United StatesDepartment of Immunobiology, University of Arizona College of Medicine, Tucson, United States; Arizona Center on Aging, University of Arizona College of Medicine, Tucson, United States; BIO-5 Institute, University of Arizona College of Medicine, Tucson, United StatesT-cell recognition of self and foreign peptide antigens presented in major histocompatibility complex molecules (pMHC) is essential for life-long immunity. How the ability of the CD4+ T-cell compartment to bind self- and foreign-pMHC changes over the lifespan remains a fundamental aspect of T-cell biology that is largely unexplored. We report that, while old mice (18–22 months) contain fewer CD4+ T-cells compared with adults (8–12 weeks), those that remain have a higher intrinsic affinity for self-pMHC, as measured by CD5 expression. Old mice also have more cells that bind individual or multiple distinct foreign-pMHCs, and the fold increase in pMHC-binding populations is directly related to their CD5 levels. These data demonstrate that the CD4+ T-cell compartment preferentially accumulates promiscuous constituents with age as a consequence of higher affinity T-cell receptor interactions with self-pMHC.https://elifesciences.org/articles/05949CD4T cellrepertoireagingclass II MHCCD5 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Neha R Deshpande Heather L Parrish Michael S Kuhns |
spellingShingle |
Neha R Deshpande Heather L Parrish Michael S Kuhns Self-recognition drives the preferential accumulation of promiscuous CD4+ T-cells in aged mice eLife CD4 T cell repertoire aging class II MHC CD5 |
author_facet |
Neha R Deshpande Heather L Parrish Michael S Kuhns |
author_sort |
Neha R Deshpande |
title |
Self-recognition drives the preferential accumulation of promiscuous CD4+ T-cells in aged mice |
title_short |
Self-recognition drives the preferential accumulation of promiscuous CD4+ T-cells in aged mice |
title_full |
Self-recognition drives the preferential accumulation of promiscuous CD4+ T-cells in aged mice |
title_fullStr |
Self-recognition drives the preferential accumulation of promiscuous CD4+ T-cells in aged mice |
title_full_unstemmed |
Self-recognition drives the preferential accumulation of promiscuous CD4+ T-cells in aged mice |
title_sort |
self-recognition drives the preferential accumulation of promiscuous cd4+ t-cells in aged mice |
publisher |
eLife Sciences Publications Ltd |
series |
eLife |
issn |
2050-084X |
publishDate |
2015-07-01 |
description |
T-cell recognition of self and foreign peptide antigens presented in major histocompatibility complex molecules (pMHC) is essential for life-long immunity. How the ability of the CD4+ T-cell compartment to bind self- and foreign-pMHC changes over the lifespan remains a fundamental aspect of T-cell biology that is largely unexplored. We report that, while old mice (18–22 months) contain fewer CD4+ T-cells compared with adults (8–12 weeks), those that remain have a higher intrinsic affinity for self-pMHC, as measured by CD5 expression. Old mice also have more cells that bind individual or multiple distinct foreign-pMHCs, and the fold increase in pMHC-binding populations is directly related to their CD5 levels. These data demonstrate that the CD4+ T-cell compartment preferentially accumulates promiscuous constituents with age as a consequence of higher affinity T-cell receptor interactions with self-pMHC. |
topic |
CD4 T cell repertoire aging class II MHC CD5 |
url |
https://elifesciences.org/articles/05949 |
work_keys_str_mv |
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