Antitumor activity of TY-011 against gastric cancer by inhibiting Aurora A, Aurora B and VEGFR2 kinases

Antitumor activity of TY-011 against gastric cancer by inhibiting Aurora A, Aurora B and VEGFR2 kinases

Abstract Background Overexpression of Aurora A and B has been reported in a wide range of tumor types, including gastric cancer. Anti-angiogenesis has been considered as an important therapeutic modality in advanced gastric cancer. Here we identified a novel compound TY-011 with promising antitumor...

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Bibliographic Details
Main Authors: Wang Liu, Yu Lu, Xiaoping Chai, Xiao Liu, Tong Zhu, Xihan Wu, Yanfen Fang, Xuan Liu, Xiongwen Zhang
Format: Article
Language:English
Published: BMC 2016-11-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Gastric cancer
Cell cycle
Angiogenesis
Polyploidy
Apoptosis
Online Access:http://link.springer.com/article/10.1186/s13046-016-0464-2

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http://link.springer.com/article/10.1186/s13046-016-0464-2

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