Doxorubicin-Loaded Delta Inulin Conjugates for Controlled and Targeted Drug Delivery: Development, Characterization, and In Vitro Evaluation

Doxorubicin-Loaded Delta Inulin Conjugates for Controlled and Targeted Drug Delivery: Development, Characterization, and In Vitro Evaluation

Delta inulin, also known as microparticulate inulin (MPI), was modified by covalently attaching doxorubicin to its nanostructured surface for use as a targeted drug delivery vehicle. MPI is readily endocytosed by monocytes, macrophages, and dendritic cells and in this study, we sought to utilize thi...

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Bibliographic Details
Main Authors: Lixin Wang, Yunmei Song, Ankit Parikh, Paul Joyce, Rosa Chung, Liang Liu, Franklin Afinjuomo, John D. Hayball, Nikolai Petrovsky, Thomas G. Barclay, Sanjay Garg
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Pharmaceutics
Subjects:
inulin
advax
doxorubicin
anticancer therapy
targeted delivery
ph sensitive
intracellular drug release
Online Access:https://www.mdpi.com/1999-4923/11/11/581

Internet

https://www.mdpi.com/1999-4923/11/11/581

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