Mitochondrial DNA damage and impaired base excision repair during epileptogenesis

Mitochondrial DNA damage and impaired base excision repair during epileptogenesis

Oxidative stress and mitochondrial dysfunction are acute consequences of status epilepticus (SE). However, the role of mitochondrial oxidative stress and genomic instability during epileptogenesis remains unknown. Using the kainate animal model of temporal lobe epilepsy, we investigated oxidative mi...

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Bibliographic Details
Main Authors: Stuart G. Jarrett, Li-Ping Liang, Jennifer L. Hellier, Kevin J. Staley, Manisha Patel
Format: Article
Language:English
Published: Elsevier 2008-04-01
Series:Neurobiology of Disease
Subjects:
Oxidative stress
Mitochondrial dysfunction
Status epilepticus
Epileptogenesis
mtDNA damage
Base excision repair
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996107002872

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http://www.sciencedirect.com/science/article/pii/S0969996107002872

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