Endosomal dysfunction in iPSC-derived neural cells from Parkinson’s disease patients with VPS35 D620N

Endosomal dysfunction in iPSC-derived neural cells from Parkinson’s disease patients with VPS35 D620N

Abstract Mutations in the Vacuolar protein sorting 35 (VPS35) gene have been linked to familial Parkinson’s disease (PD), PARK17. VPS35 is a key component of the retromer complex, which plays a central role in endosomal trafficking. However, whether and how VPS35 deficiency or mutation contributes t...

Full description

Bibliographic Details
Main Authors: Keiko Bono, Chikako Hara-Miyauchi, Shunsuke Sumi, Hisayoshi Oka, Yasuyuki Iguchi, Hirotaka James Okano
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Molecular Brain
Subjects:
Parkinson’s disease
iPSC
VPS35
Retromer
Endosomes
Online Access:http://link.springer.com/article/10.1186/s13041-020-00675-5

Internet

http://link.springer.com/article/10.1186/s13041-020-00675-5

Similar Items