Distinct mechanisms regulate Lck spatial organization in activated T cells

Distinct mechanisms regulate Lck spatial organization in activated T cells

Phosphorylation of the T cell receptor (TCR) by the kinase Lck is the first detectable signaling event upon antigen engagement. The distribution of Lck within the plasma membrane, its conformational state, kinase activity and protein interactions all contribute to determine how efficiently Lck phosp...

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Bibliographic Details
Main Authors: Natasha eKapoor-Kaushik, Elizabeth eHinde, Ewoud Bernardus Compeer, Yui eYamamoto, Felix eKraus, Zhengmin eYang, Jieqiong eLou, Thibault eTabarin, Sophie Victoria Pageon, Katharina eGaus, Jeremie eRossy
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-03-01
Series:Frontiers in Immunology
Subjects:
Lck
T cell signaling
Membrane organization
image correlation spectroscopy
Super-resolution fluorescence microscopy
assembly of signaling complexes
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00083/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00083/full

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