Synthesis and Biological Activity of 6-Selenocaffeine: Potential Modulator of Chemotherapeutic Drugs in Breast Cancer Cells

Synthesis and Biological Activity of 6-Selenocaffeine: Potential Modulator of Chemotherapeutic Drugs in Breast Cancer Cells

We report the development of a new microwave-based synthetic methodology mediated by Woollins’ reagent that allowed an efficient conversion of caffeine into 6-selenocaffeine. A preliminary evaluation on the modulation of antioxidant activity upon selenation of caffeine, using the DPPH assay, indicat...

Full description

Bibliographic Details
Main Authors: Inês L. Martins, Joana P. Miranda, Nuno G. Oliveira, Ana S. Fernandes, Sandrina Gonçalves, Alexandra M. M. Antunes
Format: Article
Language:English
Published: MDPI AG 2013-05-01
Series:Molecules
Subjects:
organoselenium compounds
caffeine
modulator of the cytoxicity
oxaliplatin
doxorubicin
cancer therapy
Online Access:http://www.mdpi.com/1420-3049/18/5/5251

Internet

http://www.mdpi.com/1420-3049/18/5/5251

Similar Items