Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases.

Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases.

Rho family GTPases (including Rac, Rho and Cdc42) collectively control cell proliferation, adhesion and migration and are of interest as functional therapeutic targets in numerous epithelial cancers. Based on high throughput screening of the Prestwick Chemical Library® and cheminformatics we identif...

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Bibliographic Details
Main Authors: Tudor I Oprea, Larry A Sklar, Jacob O Agola, Yuna Guo, Melina Silberberg, Joshua Roxby, Anna Vestling, Elsa Romero, Zurab Surviladze, Cristina Murray-Krezan, Anna Waller, Oleg Ursu, Laurie G Hudson, Angela Wandinger-Ness
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4641600?pdf=render

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http://europepmc.org/articles/PMC4641600?pdf=render

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