Mechanistic Scrutiny Identifies a Kinetic Role for Cytochrome b5 Regulation of Human Cytochrome P450c17 (CYP17A1, P450 17A1).

Mechanistic Scrutiny Identifies a Kinetic Role for Cytochrome b5 Regulation of Human Cytochrome P450c17 (CYP17A1, P450 17A1).

Cytochrome P450c17 (P450 17A1, CYP17A1) is a critical enzyme in the synthesis of androgens and is now a target enzyme for the treatment of prostate cancer. Cytochrome P450c17 can exhibit either one or two physiological enzymatic activities differentially regulated by cytochrome b5. How this is achie...

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Bibliographic Details
Main Authors: Alexandr N Simonov, Jessica K Holien, Joyee Chun In Yeung, Ann D Nguyen, C Jo Corbin, Jie Zheng, Vladimir L Kuznetsov, Richard J Auchus, Alan J Conley, Alan M Bond, Michael W Parker, Raymond J Rodgers, Lisandra L Martin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4654539?pdf=render

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http://europepmc.org/articles/PMC4654539?pdf=render

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