Large-scale transcriptome-wide association study identifies new prostate cancer risk regions
Genome-wide association studies (GWAS) have identified hundreds of genomic risk regions for prostate cancer. Here, the authors perform a transcriptome wide association study (TWAS) by incorporating prostate cancer GWAS with gene expression data to identify potential novel prostate cancer risk loci a...
Main Authors: | Nicholas Mancuso, Simon Gayther, Alexander Gusev, Wei Zheng, Kathryn L. Penney, Zsofia Kote-Jarai, Rosalind Eeles, Matthew Freedman, Christopher Haiman, Bogdan Pasaniuc, The PRACTICAL consortium |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2018-10-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-06302-1 |
Similar Items
-
Author Correction: Large-scale transcriptome-wide association study identifies new prostate cancer risk regions
by: Nicholas Mancuso, et al.
Published: (2019-01-01) -
Identification of Germline Genetic Variants That Increase Prostate Cancer Risk and Influence Development of Aggressive Disease
by: Edward J. Saunders, et al.
Published: (2021-02-01) -
Leveraging expression from multiple tissues using sparse canonical correlation analysis and aggregate tests improves the power of transcriptome-wide association studies.
by: Helian Feng, et al.
Published: (2021-04-01) -
Polygenic risk-tailored screening for prostate cancer: A benefit-harm and cost-effectiveness modelling study.
by: Tom Callender, et al.
Published: (2019-12-01) -
Comprehensive functional annotation of 77 prostate cancer risk loci.
by: Dennis J Hazelett, et al.
Published: (2014-01-01)