Abnormal Hypermethylation of CpG Dinucleotides in Promoter Regions of Matrix Metalloproteinases Genes in Breast Cancer and Its Relation to Epigenomic Subtypes and HER2 Overexpression

Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) substantially contribute to the regulation of intercellular interactions and thereby play a role in maintaining the tissue structure and function. We examined methylation of a subset of 5’-cytosine-phosphate-guanine-3’ (CpG) dinucl...

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Bibliographic Details
Main Authors: Olga A. Simonova, Ekaterina B. Kuznetsova, Alexander S. Tanas, Viktoria V. Rudenko, Elena V. Poddubskaya, Tatiana V. Kekeeva, Ivan D. Trotsenko, Sergey S. Larin, Sergei I. Kutsev, Dmitry V. Zaletaev, Marina V. Nemtsova, Vladimir V. Strelnikov
Format: Article
Published: MDPI AG 2020-05-01
Online Access:https://www.mdpi.com/2227-9059/8/5/116