Assessing the Functional Relevance of Variants in the IKAROS Family Zinc Finger Protein 1 (IKZF1) in a Cohort of Patients With Primary Immunodeficiency

Assessing the Functional Relevance of Variants in the IKAROS Family Zinc Finger Protein 1 (IKZF1) in a Cohort of Patients With Primary Immunodeficiency

Common variable immunodeficiency (CVID) is the most frequent symptomatic primary immunodeficiency. Patients with CVID are prone to recurrent bacterial infection due to the failure of adequate immunoglobulin production. Monogenetic defects have been identified in ~25% of CVID patients. Recently, muta...

Full description

Bibliographic Details
Main Authors: Zoya Eskandarian, Manfred Fliegauf, Alla Bulashevska, Michele Proietti, Rosie Hague, Cristian Roberto Smulski, Desirée Schubert, Klaus Warnatz, Bodo Grimbacher
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
CVID
monogenic defects
IKAROS
TRAIL
DNA binding
nuclear localization
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00568/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00568/full

Similar Items