Glycogen synthesis is induced in hypoxia by the hypoxia-inducible factor and promotes cancer cell survival

Glycogen synthesis is induced in hypoxia by the hypoxia-inducible factor and promotes cancer cell survival

The hypoxia-inducible factor 1 (HIF-1), in addition to genetic and epigenetic changes, is largely responsible for alterations in cell metabolism in hypoxic tumor cells. This transcription factor not only favors cell proliferation through the metabolic shift from oxidative phosphorylation to glycolys...

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Bibliographic Details
Main Authors: Joffrey ePelletier, Gregory eBellot, Pierre eGounon, Sandra eLacas-Gervais, Jacques ePouyssegur, Nathalie M. Mazure
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-02-01
Series:Frontiers in Oncology
Subjects:
Glycogen
hypoxia
HIF-1
Cancer cells
PGM1
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00018/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00018/full

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