CDK1 Inhibition Targets the p53-NOXA-MCL1 Axis, Selectively Kills Embryonic Stem Cells, and Prevents Teratoma Formation

CDK1 Inhibition Targets the p53-NOXA-MCL1 Axis, Selectively Kills Embryonic Stem Cells, and Prevents Teratoma Formation

Embryonic stem cells (ESCs) have adopted an accelerated cell-cycle program with shortened gap phases and precocious expression of cell-cycle regulatory proteins, including cyclins and cyclin-dependent kinases (CDKs). We examined the effect of CDK inhibition on the pathways regulating proliferation a...

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Bibliographic Details
Main Authors: Noelle E. Huskey, Tingxia Guo, Kimberley J. Evason, Olga Momcilovic, David Pardo, Katelyn J. Creasman, Robert L. Judson, Robert Blelloch, Scott A. Oakes, Matthias Hebrok, Andrei Goga
Format: Article
Language:English
Published: Elsevier 2015-03-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671115000405

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http://www.sciencedirect.com/science/article/pii/S2213671115000405

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