Uracil-containing DNA in Drosophila: stability, stage-specific accumulation, and developmental involvement.

Uracil-containing DNA in Drosophila: stability, stage-specific accumulation, and developmental involvement.

Base-excision repair and control of nucleotide pools safe-guard against permanent uracil accumulation in DNA relying on two key enzymes: uracil-DNA glycosylase and dUTPase. Lack of the major uracil-DNA glycosylase UNG gene from the fruit fly genome and dUTPase from fruit fly larvae prompted the hypo...

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Main Authors: Villő Muha, András Horváth, Angéla Békési, Mária Pukáncsik, Barbara Hodoscsek, Gábor Merényi, Gergely Róna, Júlia Batki, István Kiss, Ferenc Jankovics, Péter Vilmos, Miklós Erdélyi, Beáta G Vértessy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3369950?pdf=render

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http://europepmc.org/articles/PMC3369950?pdf=render

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