Nonintegrating Lentiviral Vector-Based Vaccine Efficiently Induces Functional and Persistent CD8+ T Cell Responses in Mice

Nonintegrating Lentiviral Vector-Based Vaccine Efficiently Induces Functional and Persistent CD8+ T Cell Responses in Mice

CD8+ T cells are an essential component of an effective host immune response to tumors and viral infections. Genetic immunization is particularly suitable for inducing CTL responses, because the encoded proteins enter the MHC class I processing pathway through either transgene expression or cross-pr...

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Bibliographic Details
Main Authors: Donatella R. M. Negri, Zuleika Michelini, Silvia Baroncelli, Massimo Spada, Silvia Vendetti, Roberta Bona, Pasqualina Leone, Mary E. Klotman, Andrea Cara
Format: Article
Language:English
Published: Hindawi Limited 2010-01-01
Series:Journal of Biomedicine and Biotechnology
Online Access:http://dx.doi.org/10.1155/2010/534501

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http://dx.doi.org/10.1155/2010/534501

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