Advanced Glycation Endproducts Are Increased in the Animal Model of Multiple Sclerosis but Cannot Be Reduced by Pyridoxamine Treatment or Glyoxalase 1 Overexpression

Advanced Glycation Endproducts Are Increased in the Animal Model of Multiple Sclerosis but Cannot Be Reduced by Pyridoxamine Treatment or Glyoxalase 1 Overexpression

Multiple sclerosis (MS) is a demyelinating autoimmune disease of the central nervous system (CNS). The immune response in MS patients leads to the infiltration of immune cells in the CNS and their subsequent activation. Immune cell activation induces a switch towards glycolysis. During glycolysis, t...

Full description

Bibliographic Details
Main Authors: Suzan Wetzels, Kristiaan Wouters, Toshio Miyata, Jean L. J. M. Scheijen, Jerome J. A. Hendriks, Casper G. Schalkwijk, Tim Vanmierlo
Format: Article
Language:English
Published: MDPI AG 2018-04-01
Series:International Journal of Molecular Sciences
Subjects:
advanced glycation endproducts
pyridoxamine
glyoxalase-1
experimental autoimmune encephalomyelitis
multiple sclerosis
Online Access:http://www.mdpi.com/1422-0067/19/5/1311

Internet

http://www.mdpi.com/1422-0067/19/5/1311

Similar Items