Single Domain Antibody-Mediated Blockade of Programmed Death-Ligand 1 on Dendritic Cells Enhances CD8 T-cell Activation and Cytokine Production

Single Domain Antibody-Mediated Blockade of Programmed Death-Ligand 1 on Dendritic Cells Enhances CD8 T-cell Activation and Cytokine Production

Dendritic cell [DC] vaccines can induce durable clinical responses, at least in a fraction of previously treated, late stage cancer patients. Several preclinical studies suggest that shielding programmed death-ligand 1 [PD-L1] on the DC surface may be an attractive strategy to extend such clinical b...

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Bibliographic Details
Main Authors: Katrijn Broos, Quentin Lecocq, Brenda De Keersmaecker, Geert Raes, Jurgen Corthals, Eva Lion, Kris Thielemans, Nick Devoogdt, Marleen Keyaerts, Karine Breckpot
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Vaccines
Subjects:
human
PD-L1
dendritic cell
vaccination
single domain antibody
nanobody
cancer
immunotherapy
Online Access:https://www.mdpi.com/2076-393X/7/3/85

Internet

https://www.mdpi.com/2076-393X/7/3/85

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